Wednesday, November 30, 2011

What are the virulence factor of extra-intestinal pathogenic E. coli?

According to Todar's Online Textbook of Bacteriology, the virulence factors of extra-intestinal pathogenic E. coli are as follows:
-Adhesins-
CFAI/CFAII
Type 1 fimbriae
P fimbriae
S fimbriae
Intimin (non-fimbrial adhesin)
-Invasins-
hemolysisn
siderophores and siderophore uptake systems
Shigella-like "invasins" for intracellular invasion and spread
-Motility/chemotaxis-
flagella
-Toxins-
LT toxin
ST toxin
Shiga-like toxin
cytotoxins
endotoxin LPS)
-Antiphagocytic surface properties-
capsule
K antigens
LPS
-Defense against serum bactericidal reactions-
LPS
K antigens
-Defense against immune responses-
capsules
K antigens
LPS
antigenic changeability
-Genetic attributes-
genetic exchange by transduction and conjugation
transmissible plasmids
R factors and drug resistance plasmids
toxin and other virulence plasmids
That depends on which E. coli you're discussion about. There are enterotoxigenic, enterohemorrhagic, enteropathogenic, entero-invasive, enteroaggregative and diffuse-adherent strains. Which do you want to know just about so I don't have to write out everything.?

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